PhD Vacancy - Establishing a Dosimetry Framework for Very High Energy Electron (VHEE) Radiotherapy

About the Role

Very High Energy Electron (VHEE) radiotherapy is an exciting frontier in cancer treatment, offering a powerful combination of deep tissue penetration and sharp dose gradients through electron beams in the 50–250 MeV range. Unlike conventional electron therapy, VHEE enables precise targeting of deep-seated tumours while minimizing healthy tissue damage. Its compatibility with advanced delivery techniques, such as pencil beam scanning and utilization of the FLASH effect (providing sparing of normal healthy tissue), make it a strong candidate for next-generation radiotherapy. As global interest in VHEE accelerates, one of the most pressing challenges is the absence of a standardized dosimetry framework. Accurate and reproducible dose measurement traceable to primary standards is essential for clinical safety, treatment planning, and quality assurance. However, current protocols are not optimized for the unique characteristics of VHEE beams.

This PhD project offers a unique opportunity to contribute to the foundational infrastructure of VHEE radiotherapy. The research will focus on developing and validating a robust dosimetry framework under reference conditions, aligned with national and international standards and dosimetry protocols. Central to the work are experimental measurements using large-area integrating detectors, including calorimeters and ionization chambers. The candidate will work closely with scientists from the National Physical Laboratory and carry out systematic investigations using both in-house developed and commercial instrumentation, assessing their performance in VHEE environments. Measurements will be conducted at leading VHEE research facilities in the UK and Europe, providing access to cutting-edge technology and collaborative expertise. To complement the experimental work, Monte Carlo radiation transport simulations will be employed to support data analysis and refine measurement protocols. This is a rare opportunity to be at the forefront of a rapidly evolving field, contributing to research that could shape the future of cancer treatment and pave the way for safe and effective clinical implementation of VHEE.

About You

Candidate Requirements Essential Qualifications and Skills: Academic Background: A first-class or upper second-class degree (or equivalent) in Physics, Medical Physics, Radiation Physics, Engineering, or a closely related discipline. Technical Knowledge: Solid understanding of radiation physics, dosimetry principles, and particle interactions with matter. Analytical Thinking: Ability to design experiments, interpret complex datasets, and troubleshoot technical challenges. Communication: Strong written and verbal communication skills for reporting results and collaborating with multidisciplinary teams. Teamwork: Ability to work effectively in collaborative research environments and engage with external partners. Desirable Experience: Experimental Skills: Hands-on experience with laboratory measurements, instrumentation, and data acquisition systems.

Computational Skills: Proficiency in Monte Carlo simulations (e.g., Geant4, FLUKA) or similar radiation transport codes; strong data analysis skills using tools such as Python or MATLAB. Prior experience in radiotherapy physics, accelerator-based research, or high-energy particle beams. Experience with high-performance computing for simulation tasks. Personal Attributes: Highly motivated and enthusiastic about advancing cancer treatment technologies. Strong problem-solving skills and attention to detail. Willingness to travel to UK and European research facilities for experimental campaigns. link to UCL's project catalogue:

Link to apply:

For technical inquires please contact Anna Subiel ([email protected])

About Us

The National Physical Laboratory (NPL) is a world-leading centre of excellence that provides cutting-edge measurement science, engineering and technology to underpin prosperity and quality of life in the UK.

NPL and DSIT have strong commitments to diversity and equality of opportunity, and welcome applications from candidates irrespective of their background, gender, race, sexual orientation, religion, or age, providing they meet the required criteria. Applications from women, disabled and black, Asian and minority ethnic candidates in particular are encouraged. All disabled candidates (as defined by the Equality Act 2010) who satisfy the minimum criteria for the role will be guaranteed an interview under the Disability Confident Scheme.

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