Senior Laboratory Research Scientist - Metabolomics/Lipidomics Specialist

Job Title: Senior Laboratory Research Scientist: Metabolomics and/or Lipidomics Specialist

Reports to: James MacRae (Head of Metabolomics)

Contract: This is a full-time, permanent position on Crick terms and
conditions of employment. Working pattern: Monday-Friday.

Salary : SLRS level from £45,700 per annum plus benefits. The role is advertised as a Senior Laboratory Research Scientist; the appropriate level will be assigned to the successful candidate subject to skills and experience.

About us…

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role…

This role in the Metabolomics Scientific Technology Platform (STP) will encompass discovery and targeted metabolomics in the context of biological research, as well as development of new methods to push the boundaries of metabolomics research. The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse biological research across the Crick, from large clinical cohort discovery studies to intricate analysis of metabolic activity.

Key elements of the role will include metabolomics and lipidomics using high-end LC-MS and GC-MS instruments. Innovation is a central remit of the role; the post holder will be required to identify areas of need and lead method development accordingly.

The post holder will drive projects in collaboration with Crick research groups and will be expected to take projects from initial concept and design, through sample preparation and data acquisition, and on to data processing and analysis.

What you will be doing…

As an SLRS in the Crick Metabolomics STP, your role will cover:

• Metabolomics, lipidomics, and mass spectrometry projects (40%). Operation and maintenance of mass spectrometers – particularly LC-MS and GC-MS. Driving metabolomics projects, including experimental design, stable isotope labelling techniques, and novel method development.
• Data analysis and computational work (35%). Effective use of data analysis software to process and analyse MS data, including statistical analyses (i.e. univariate and multivariate analyses).
• Training (15%). Training of others in the operation of the LC-MS & GC-MS instrumentation and metabolomics/lipidomics workflows.
• Laboratory management (10%). Maintenance of successful day to day operation of the laboratory, including maintenance of safety standards, purchasing, and general organisation, among others.

About you…

(Minimum Criteria*)

The essential criteria you will bring…

• Ph.D. or equivalent, in Metabolomics, Biochemistry, Analytical Chemistry, or other relevant, related discipline.*
• Significant experience in operation, maintenance, and troubleshooting of hyphenated-mass spectrometry (in particular, LC-MS & GC-MS).*
• Significant experience in performance of metabolomics/lipidomics experiments (including experimental design, metabolite extraction, sample preparation, data acquisition, and method development).* Stable isotope labelling experience is highly desirable.
• Experience in relevant data processing, analysis, and statistics (including MS/metabolomics software workflows, targeted and profiling approaches, univariate and multivariate analyses, power calculations, etc).*
• Experience in design/implementation of new analytical methods.
• Knowledge of experimental design and metabolomics procedures in the context of large cohort studies.
• Ability to work with day-to-day independence with good oral and written communication skills.
• Open and interactive with line manager, laboratory colleagues, and peers.
• Organisational and time-management skills to be able to perform to strict deadlines.

To see the complete job description, click here .

To learn more about Metabolomics click here .

About Working at the Crick…

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture:

• We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.

• We are open . We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.

• We are collegial . We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: [email protected]

To find out more about life at the Crick click here .

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
• Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays.

• Pension Scheme : Defined contribution pension with employer contributions of up to 16%.

• Health & Well-being :

• 24/7 GP consultation services.

• Occupational health services and mental health support programs.

• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance :

• Back-up care for dependents.

• Childcare support allowance.

• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.

• Perks :

• Discounted gym memberships, bike-to-work scheme, and shopping discounts.

• Subsidised on-site restaurant and social spaces for team interaction.

• Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

Company

At the Crick, we’re committed to advancing, promoting, and sharing understanding of human health and disease. We do that by attracting talented and ambitious people from all disciplines and backgrounds and giving them the support and freedom they need to succeed. Inside the Crick, you’ll discover scientists working to stretch the very limits of what we know about how life works. Their research holds the key to answering fundamental questions about human health and disease. Our bold and innovative research projects bring together scientists and technicians from all disciplines in the pursuit of discovery without boundaries. With the support of our partners, we’re bridging the gap between discovery and application to help change lives for the better. And through our dynamic structure, we’re able to develop the science leaders of tomorrow. That’s our bold idea, tell us yours.

Company info

Location

London
NW1 1AT
United Kingdom